SARS 非典型肺炎相关医学全文文献

检索关键词：SARS 或： Severe Acute Respiratory Syndrome

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新英伦医学期刊 (New England Journal of Medicine)网上文章 香港医院管理局对SARS 非典发出之指引 - 包含临床诊断， 治疗方法，保护措施等.请按此。 WHO 世界卫生组织有关SARS之网上发布文章。SARS 选读

Outbreak of severe acute respiratory syndrome in Hong Kong Special Administrative Region: case report.[Article] (香港非典个案研究)

Source

BMJ. 326(7394):850-852, April 19, 2003.

Abstract

Objective: To describe the outbreak of severe acute respiratory syndrome in Hong Kong.

Design: Descriptive case series.Setting: Hong Kong, Special Administrative Region, China

Results: The outbreak started with a visitor from southern China on 21 February. At the hospitals where the first cases were treated the disease spread quickly among healthcare workers, and then out into the community as family members became infected. By 1 April, 685 cases had been reported with 16 deaths. Symptoms include high fever and one or more respiratory symptoms (including cough, shortness of breath, and difficulty breathing). Changes in lung tissue suggest that part of the lung damage is due to cytokines induced by the microbial agent, which has led to empirical treatment with corticosteroids, broad spectrum antiviral agent, and antibacterial cover. There is strong evidence that a novel coronavirus is the pathogen. Precautions for droplet infection should be instituted, including the wearing of masks and rigorous disinfection and hygiene procedures. On 27 March the Department of Health announced drastic measures, including vigorous contact tracing and examination, quarantine of contacts in their homes, and closure of all schools and universities.

Conclusion: The rapidity of the spread of the disease and the morbidity indicate that the agent responsible is highly infectious and virulent. Strict infection control measures for droplet and contact transmission by healthcare workers, a vigilant healthcare profession, and public education are essential for disease prevention.

(C) British Medical Journal 2003.