[内容简介]
This book introduces and discusses the latest in biomedical research—Pharmaceutical Nanotechnology applied at the sub-cellular level.
[目次]
Preface ix
Contributors xi
1 An Introduction to Subcellular Nanomedicine: Current Trends and Future Developments Gerard G. M. D'Souza Volkmar Weissig 1
2 Delivery of Nanonsensors to Measure the Intracellular Environment Paul G. Coupland Jonathan W. Aylott 15
3 Cytoplasmic Diffiusion of Dendrimers and Dendriplexes Alexander T. Florence Pakatip Ruenraroengsak 35
4 Endocytosis and Intracellular Trafficking of Quantum Dot-Ligand Bioconjugates Tore-Geir Iversen Nadine Frerker Kirsten Sandvig 55
5 Synthesis of Metal Nanoparticle-Based Intracellular Biosensors and Therapeutic Agents Neil Bricklebank 73
6 Subcellular Fate of Nanodelivery Systems Dusica Maysinger Sebastien Boridy Eliza Hutter 93
7 Intracellular Fate of Plasmid DNA Polyplexes Kevin Maier Ernst Wagner 123
8 Intracellular Trafficking of Membrane Receptor-Mediated Uptake of Carbon Nanotubes Bin Kang Yaodong Dai 143
9 Real-Time Particle Tracking for Studying Intracellular Transport of Nanotherapeutics Clive Chen Junghae Suh 161
10 Tracking Intracellular Polymer Localization Via Fluorescence Microscopy Simon C. W. Richardson 177
11 Can QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips for Predicting Uptake and Localization of Nanoparticles in Living Cells? And If Not, Why Not? Richard W.
Horobin 193
12 Self-Unpacking Gene Delivery Scaffolds Millicent O. Sullivan 207
13 Cellular Trafficking of Dendrimers Yunus Emre Kurtoglu Rangaramanujam M. Kannan 231
14 Endolysosomolytically Active pH-Sensitive Polymeric Nanotechnology Han Chang Kang You Han Bae 247
15 Uptake and Intracellular Dynamics of Proteins Internalized by Cell-Penetrating Peptides Arwyn T. Jones 263
16 Cargo Transport by Teams of Molecular Motors: Basic Mechanisms for Intracellular Drug Delivery Melanie J. I. Müller Florian Berger Stegan Klumpp Reinhard Lipowsky 289
17 The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines Kristian Berg Anette Weyergang Anders Høgset Pål Kristian Selbo 311
18 Peptide-Based Nanocarriers for Intracellular Delivery of Biologically Active Proteins Seong Loong Lo Shu Wang 323
19 Organelle-Specific Pharmaceutical Nanotechnology: Active Cellular Transport of Submicro-and Nanoscale Particles Galya Orr 337
20 Subcellular Targeting of Virus-Envelope-Coated Nanoparticles Jia Wang Mohammad F. Saeed Andrey A. Kolokoltsov Robert A. Davey 357
21 Mitochondria-Targeted Pharmaceutical Nanocarriers Volkmar Weissig Gerard G.M. D'Souza 385
22 Cell-Penetrating Peptides for Cytosolic Delivery of Biomacromolecules Camilla Foged Xiaona Jing Hanne Moerck Nielsen 403
23 Therapeutic Nano-object Delivery to Subdomains of Cardiac Myocytes Valeriy Lukyanenko 433
24 Design Parameters Modulating Intracellular Drug Delivery: Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of Auxiliary Pharmacological Agents Silvia Muro Vladimir R.
Muzykantov 449
25 Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery Systems Ikramy A. Khalil Yuma Yamada Hidetaka Akita Hideyoshi Harashima 475
26 Cellular Interactions of Plasmon-Resonant Gold Nanorods Qingshan Wei Alexander Wei 507
27 Quantum Dot Labeling for Assessment of Intracellular Trafficking of Therapeutically Active Molecules Diane J. Burgess Mamta Kapoor 535
Index 569