Bacterial Pili: Structure, Synthesis and Role in Disease
[Book Description]
Bacterial pili play important roles as environmental sensors, in host colonization and in biofilm formation, enabling bacteria to interact with the environment, with surfaces and with other bacteria and host cells. Most bacteria, both Gram positive and Gram negative, and almost all bacterial pathogens, are piliated. This book discusses the synthesis, structure, evolution, function and role in pathogenesis of these complex structures, and their basis for vaccine development and therapeutics for Streptococcus pathogens.
[Table of Contents]
Contributors ix
Foreword xi
Michele A. Barocchi
John L. Telford
1 The Vibrio cholerae Toxin Coregulated 1 (16)
Pilus: Structure, Assembly and Function
with Implications for Vaccine Design
Lisa Craig
Ronald K. Taylor
2 Conjugative Pili 17 (19)
Peter J. Christie
3 Pilus Biogenesis by the Chaperone-Usher 36 (13)
Pathway
Gilles Phan
Gabriel Waksman
4 Type 1 and P Pili of Uropathogenic 49 (22)
Escherichia coli
Colin Russell
Matthew Mulvey
5 Type IV Pili: Functions and Biogenesis 71 (14)
Michaella Georgiadou
Vladimir Pelicic
6 The Pseudomonas aeruginosa Type IV Pilus 85 (15)
Assembly System in Three Dimensions
Stephanie Tammam
P. Lyme Howell
Lori L. Burrows
7 Corynebacterium diphtheriae Pili: 100(12)
Assembly, Structure and Function
I-Hsiu Huang
Hung Ton-That
8 Three-dimensional Structures of Pilin 112(13)
Subunits and their Role in Gram-positive
Pilus Assembly and Stability
Neil G. Paterson
Edward N. Baker
9 Sortase Structure and Specificity in 125(13)
Streptococci
Roberta Cozzi
Domenico Maione
Daniela Rinaudo
10 Pili of Streptococcus pyogenes 138(13)
June R. Scott
11 The Role of Pili in the Formation of 151(14)
Biofilm and Bacterial Communities
Andrea G.O. Manetti
Tiziana Spadafina
12 Fimbriae/Pili from Oral Bacteria 165(17)
Haley Echlin
Hui Wu
13 Pilus-based Vaccine Development in 182(21)
Streptococci: Variability, Diversity and
Immunological Responses
Daniela Rinaudo
Monica Moschioni
Index 203
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