The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
List of contributors ix
Preface xiii
Section 1 General
1 Behavior genetics: where do we come from 1 (4)
and where are we going?
Wim E. Crusio
Robert T. Gerlai
2 Natural neurobiology and behavior of the 5 (12)
mouse: relevance for behavioral studies in
the laboratory
Hans-Peter Lipp
David P. Wolfer
3 Ethogram of the mouse 17 (6)
Wim E. Crusio
Frans Sluyter
Robert T. Gerlai
4 Replicability and reliability of 23 (13)
behavioral tests
Douglas Wahlsten
John C. Crabbe
Section 2 Perception
5 Audition 36 (9)
James F. Willott
6 Behavioral measurement of mouse visual 45 (10)
function
Glen T. Prusky
Nazia M. Alam
7 Tactile system and nociception 55 (10)
Shad B. Smith
Jeffrey S. Mogil
8 Olfactory acuity in Mus musculus 65 (7)
Heather Schellinck
Burton Slotnick
9 Taste genetics 72 (9)
John D. Boughter, Jr.
Section 3 Autonomous and motor behaviors
10 Motor coordination in inbred mouse 81 (7)
strains and the crucial role of the
cerebellum
Robert Lalonde
Catherine Strazielle
11 Reflex development 88 (9)
Francesca Cirulli
Enrico Alleva
12 Feeding and drinking 97 (12)
Richard J. Bodnar
Sarah R. Lewis-Levy
Benjamin Kest
13 Getting it right: learning and memory 109 (19)
determines hand-preference behavior in the
mouse
Fred G. Biddle
Brenda A. Eales
14 Rhythms and sleep: circadian and 128 (20)
seasonal activity patterns
Bernard Possidente
15 The genetics of exploratory behavior 148 (7)
Wim E. Crusio
16 Strains, SNPs, and selected lines: 155 (8)
genetic factors influencing variation in
murine anxiety-like behavior
Andrew Holmes
17 Genetic influences on infant mouse 163 (8)
ultrasonic vocalizations
Robert H. Benno
Martin E. Hahn
18 Startle behavior and prepulse inhibition 171 (8)
Claudia F. Plappert
Peter K. D. Pilz
19 Mouse models of stress-induced 179 (16)
depression-like behavior: stress
vulnerability and antidepressant response
as traits
Howard K. Gershenfeld
20 Behavioral phenotyping of mouse grooming 195 (10)
and barbering
Peter R. Canavello
Jonathan M. Cachat
Peter C. Hart
Dennis L. Murphy
Allan V. Kalueff
Section 4 Social behavior
21 Social behaviors in wild and laboratory 205 (13)
mice with a special emphasis on the
C57BL/6J inbred strain
D. Caroline Blanchard
Jacqueline N. Crawley
Hiroyuki Arakawa
Robert J. Blanchard
22 Mouse sex: sexual differentiation and 218 (12)
sexual behavior in Mus musculus
Lee Niel
Douglas A. Monks
23 Thermoregulatory behavior and the 230 (12)
genetic correlation structure of adaptive
phenotypes in house mice
Abel Bult-Ito
24 Aggression 242 (12)
Stephen C. Maxson
Sietse F. de Boer
Frans Sluyter
Section 5 Learning and memory
25 Latent inhibition 254 (13)
Thomas J. Gould
Sheree F. Logue
26 Executive function: response inhibition, 267 (10)
attention, and cognitive flexibility
Sheree F. Logue
Thomas J. Gould
27 Water navigation tasks 277 (14)
David P. Wolfer
Giovanni Colacicco
Hans Welzl
28 Active and passive avoidance 291 (8)
Igor Branchi
Laura Ricceri
29 Radial maze 299 (5)
Wim E. Crusio
Herbert Schwegler
30 Other mazes 304 (11)
Timothy P. O'Leary
Richard E. Brown
31 Cued and contextual fear conditioning 315 (10)
Robert T. Gerlai
32 Taste and odor 325 (6)
Hans Welzl
David P. Wolfer
33 Object recognition in the mouse 331 (7)
Ekrem Dere
Armin Zlomuzica
Maria A. De Souza Silva
Joseph P. Huston
Index 338
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