【内容简介】This book looks at the mathematical foundations of the modelscurrently in use. This is crucial for the correct interpretation ofthe outputs of the models. A bioinformatician should be able notonly to use software packages， but also to know the mathematicsbehind these packages. From this point of view， mathematicsdepartments throughout the world have a major role to play inbioinformatics education by teaching courses on the mathematicalfoundations of the subject. Based on the courses taught by theauthor the book combines several topics in biological sequenceanalysis with mathematical and statistical material required forsuch analysis.
【目次】1 introduction: biological sequences
2 sequence alignment
3 markov chains and hidden markov models
4 protein folding
5 phylogenetic reconstruction
6 elements of probability theory
7 significance of sequence alignment scores
8 elements of statistics
9 substitution matrices
references
index