Biochemistry = 生物化学-西安交通大学图书馆

Biochemistry = 生物化学

发布日期:2009-12-09 浏览次

【内容简介】生物化学(供临床医学口腔医学药学与制药工程专业用)》是双语教材，总结多年教学中沉淀的经验，按照医学各专业的特点，将生物化学划分为生物大分子的结构与功能、物质代谢、基因表达和专题篇4个部分，努力构建系统化课程，从学生兴趣、认知规律和探究方便出发合理设计教材的结构，注意联系实际，适度扩大学生的知识面和应用能力，突出教材中知识结构的科学化。并以鲜活灵动的色彩、图文并茂的版面、熟悉的例子吸引刚入门的医学生，让学生感受课程学习的趣味性和挑战性，将是一系统性强、可读性强、深受学生喜爱的教材。
【目次】PART Ⅰ : STRUCTURE AND FUNCTION OF BIOMACROMOLECULE
Chapter 1 Structure and Function of Protein
SECTION 1 THE COMPOSITION OF PROTEIN
1.1 Amino acid
1.2 Peptide
1.3 Some small polypeptides have biological activity
SECTION 2 MOLECULAR STRUCTURE OF PROTEINS
2.1 Primary structure
2.2 Secondary structure
2.3 Tertiary structure
2.4 Major noncovalent bond
2.5 Quaternary structure
SECTION 3 RELATION BETWEEN STRUCTURE AND FUNCTION OF PROTEINS
3.1 Primary structure and potential function of protein
3.2 Spatial structure shows the function of protein
SECTION 4 CHEMICAL AND PHYSICAL PROPERTIES OF PROTEINS
4.1 Ultraviolet absorption spectrum of protein
4.2 Isoelectric point (pI)
4.3 Denaturation of protein
SECTION 5 ISOLATION, PURIFICATION AND SEQUENCING OF PROTEINS
5.1 Dialysis and ultrafiltration
5.2 Precipitation with acetone, salting precipitation and immunoprecipitation
5.3 Chromatographic separations
5.4 Electrophoresis
5.5 Ultracentrifugation
SUMMARY
Chapter 2 Chemistry of Nucleic Acids
SECTION 1 MOLECULAR COMPOSITION OF NUCLEIC ACIDS
1.1 Basic components
1.2 Nucleosides
1.3 Mononucleotides
SECTION 2 MOLECULAR STRUCTURES OF DNA
2.1 Primary structure of nucleic acid
2.2 Chargaff's rules
2.3 Secondary structure of DNA
SECTION 3 PHYSICO-CHEMICAL PROPERTIES OF NUCLEIC ACIDS
3.1 Viscosity
3.2 Ultraviolet absorption
3.3 Denaturation and renaturation of DNA
3.4 Hydrolysis of acid or alkali
SECTION 4 STRUCTURES OF RNA
4.1 Messenger RNA
4.2 Transfer RNA
4.3 Ribosomal RNA
SUMMARY
Chapter 3 Enzymes
SECTION 1 THE MOLECULAR COMPOSITION AND FUNCTION OF ENZYMES
1.1 The molecular composition of enzymes
1.2 The active center of enzymes
1.3 Many enzymes require cofactors
SECTION 2 PROPERTIES AND MECHANISM OF ENZYME CATALYSIS
2.1 Remarkable properties of enzymes
2.2 Mechanism of enzyme catalysis
SECTION 3 THE KINETICS OF ENZYME CATALYSIS
3.1 Catalysis occurs at the active site
3.2 Multiple factors affect the rates of enzyme-catalyzed reactions
3.3 Initial rate is proportionate to enzyme concentration
3.4 Substrate concentration affects reaction rate
3.5 The Michaelis-Menten equations model the effects of substrate concentration
3.6 Kinetic analysis distinguishes competitive from noncompetitive inhibition
SECTION 4 ZYMOGENS AND ISOZYMES
4.1 Zymogens and zymogen activation
4.2 Isozymes are physically distinct forms of the same catalytic activity
SECTION 5 THE NAME AND CLASSIFICATION OF ENZYMES
SECTION 6 THE QUANTITATIVE ANALYSIS OF CERTAIN PLASMA ENZYMES IS OF DIAGNOSTIC SIGNIFICANCE
6.1 Low levels of nonfunctional plasma enzymes result from normal destruction of cells
6.2 Nonfimcfional plasma enzymes aid diagnosis and prognosis
SUMMARY

PART Ⅱ:METABOLISM
Chapter 4 Metabolism of Carbohydrate
SECTION 1 DIGESTION OF DIETARY CARBOHYDRATES
SECTION 2 GLYCOLYSIS
2.1 Concept ofglycolysis
2.2 Glycolytic pathway
2.3 Regulation ofglycolysis
2.4 Lactate metabolism
SECTION 3 THE PYRUVATE DEHYDROGENASE COMPLEX AND THE CITRIC ACID CYCLE
3.1 The pyruvate dehydrogenase complex
3.2 Regulation of the PDH complex
3.3 Reactionsofthe tricarboxylic acid cycle
SECTION 4 PENTOSE PHOSPHATE PATHWAY
4.1 Reactions of the pentose phosphate pathway
4.2 The functions of this pathway
4.3 Erythrocytes and the pentose phosphate pathway
4.4 Pentose phosphate pathway with disease
SECTION 5 GLYCOGEN METABOLISM
5.1 Glycogen synthesis
5.2 Glyeogenolysis
5.3 The functions ofglycogenesis and glycogenolysis
SECTION 6 GLUCONEOGENESIS
6.1 Gluconeogenesis
6.2 Regulation of gluconeogenesis
SECTION 7 REGULATION OF BLOOD SUGAR LEVELS
SUMMARY
Chapter 5 Biological Oxidation
SECTION 1 THE WAY OF OXIDATION
1.1 Additionofoxygen
1.2 Removal of electrons
1.3 Dehydrogenation
SECTION 2 RESPIRATORY CHAIN
2.1 The composition of respiratory chains
2.2 Two capital kinds of respiratory chains
2.3 Oxidative phosphorylation
2.4 Factors of influence on oxidative phosphorylation
2.5 Shuttle systems are required for mitochondrial oxidation ofcytosolic NADH
SUMMARY
Chapter 6 Lipid Metabolism
SECTION 1 DIGESTION AND ABSORPTION OF LIPIDS
SECTION 2 BLOOD LIPIDS AND LIPOPROTEINS
2.1 The composition and content of blood lipoprotein
2.2 The classification of lipoproteins
SECTION 3 INTERMEDIATE METABOLISM OF TRIACYLGLYCEROLS
3.1 Hydrolysis oftriacylglycerols in adipose tissue
3.2 Oxidation of fatty acids
3.3 Fatty acid synthesis
3.4 Biosynthesis oftriacylglycerol
SECTION 4 METABOLISM OF PHOSPHOLIPIDS
SECTION 5 CHOLESTEROL METABOLISM
5.1 Biosynthesis of cholesterol
5.2 Transformation and excretion of cholesterol
SUMMARY
Chapter 7 Amino Acid Metabolism
SECTION 1 NUTRITION OF PROTEINS
1.1 Nutrition of the proteins
1.2 Nitrogen balance and protein requirements
1.3 The biosynthetic pathways of amino acids
SECTION 2 DIGESTIONANDABSORPTION OF PROTEINS
2.1 Protein turnover occurs in all forms of life
2.2 Proteases and peptidases degrade proteins to amino acids
SECTION3 AMINO ACID CATABOLISM
3.1 Overall view
3.2 Deamination ofarnino acids
3.3 Metabolism of the carbon skeletons of amino acids
SECTION 4 METABOLISM OF AMMONIA
4.1 Sources and disposals of blood ammonia
4.2 Transport of ammonia
4.3 Inter-organ exchange maintains circulating levels of amino acids
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