【内容简介】
Cancer chemotherapy can be traced back to the 1940a (TM)s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.
【目次】
Preface Part I. Sensitization via membrane-bound receptors
1. Sensitization of epithelial cancer cells with human monoclonal antibodies Peter Vollmers and Stephanie Brandlein
2. Targeting the transferrin receptor to overcome resistance to anti-cancer agents Tracy R. Daniels, Isabel I. Neacato, Gustavo Helguera, Manuel L. Penichet
3. Chemo-immunosensitization of resistant B-NHL as a result of rituximab (anti CD20 mAb)-mediated inhibition of cell survival signaling pathways Benjamin Bonavida, Ali R. Jazirehi, Mario I. Vega, Sara Huerta-Yepez, Kazuo Umezawa, and Eriko Suzuki
4. Agents that regulate DR5 and sensitivity to TRAIL Tatsushi Yoshida and Toshiyuki Sakai
5. Proteasome inhibition: Potential for sensitization of immune effector mechanisms in cancer Milad Motarjemi, William H.D. Hallett, Minghui Li, and William J. Murphy
Part II. Sensitization via inhibition of cell survival pathways (excluding apoptotic signaling pathways)
6. Angiogenesis inhibitors as chemosensitizing agents for the treatment of metastatic disease Giulio Francia, Urban Emmenegger, and Robert S. Kerbel.
7. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK and P13K/Akt pathways to sensitize cancer cells to therapy James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, illiam H. Chappell, Melissa L. Midgett, Ellis WT. Wong, Stephen L. Abrams, ristin M. Stadelman, Negin Misaghian, Dale E. Lugwid, Jorg Basecke, Massimo ibra, Franca Stivala, Michele Milella, Agostino Tafuri, Alberto M. Martelli, aolo Lungi, Antonio Bonati, David M. Terrian, Brian D. Lehmann, and Linda S. Steelman
8. Histone deacetylase inhibitors and anti-cancer activity Roberto R. Rosato and Steven Grant
9. Eicosanoids and resistance of cancer cells to chemotherapeutic agents
Andrey Sorokin
Part III. Sensitization via transcription factors
10. The RKIP and STAT3 axis in cancer chemotherapy: opposites attract Devasis Chatterjee, Edmond Sabo, Murray B. Resnick, Kam C. Yeung, and Y. Eugene Chin
11. Targeting transcription factors with decoy oligonucelotides: modulation of the expression of genes involved in chemotherapy resistance of tumor cells Roberto Gambari
12. p53 inhibitors as cancer sensitizing agents Flavio Maina and Rosanna Dono
13. Nitric Oxide-Induced Immunosensitization to Apoptosis by Fas-L and TRAIL Benjamin Bonavida, Sara Huerta-Yepez, Mario I. Vega, Demetrios A. Spandidos and Stravoula Baritaki
14. Natural agents that can sensitize tumor cells to chemotherapy and radiation therapy Ganesh Jagetia, Sunil Krishnan, and Bharat B. Aggarwal
Part IV. Sensitization via targeting apoptotic pathways
15. Inhibitors of the Bcl-2 protein family as sensitizers to anticancer agents Daniel E. Johnson
16. Therapeutic targeting of apoptosis in cancer Timothy R. Wilson, Daniel B. Longley, and Patrick G. Johnston
17. Peptides and peptidomimetics as cancer therapy sensitizing agents Shantanu Banerji, Sudharsana Rao Ande, Subbareddy Maddika, Versha Banerji, Iran Rashedi, Neil W. Owens, Anne Zuse, Frank Schweizer, and Marek Los
18. Nonpeptidic mimetics as cancer sensitizing agents Ruud P.M. Dings, Mark Klein, and Kevin H. Mayo
19. Sensitization of cancer cells to cancer therapies by isoflavone and its synthetic derivatives Fazlul H. Sarkar and Yiwei Li
20. Antisense oligonucelotides and siRNA as specific inhibitors of gene expression: mechanisms of action and therapeutic potentitial
AS-ODN and siRNA: mechanisms and therapeutic potential Yvonne Forster and Bernd Schwenzer Part V. Sensitization tailored to individual patients
21. DNA polymorphisms affecting chemosensitivity towards drugs Thomas Efferth and Michael Win
22. Pharmacogenetics in Cancer Management: Scenario for Tailored Therapy Erika Cecchin, Massimo Libra, Calogero Cannavo, Bibiana Bruni, Alberto Fulvi, Giuseppe Toffoli, and Franca Stivala