A Handbook for DNA-encoded Chemistry : Theory and Applications for Exploring Chemical Space and Drug Discovery

[Book Description]

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

[Table of Contents]

Preface                                            vii
Acknowledgments                                    ix
Introductory Comments                              xi
Contributors                                       xxiii
    1 Just Enough Knowledge...                     1    (18)
          Agnieszka Kowalczyk
    2 A Brief History of the Development of        19   (26)
    Combinatorial Chemistry and the Emerging
    Need for DNA-Encoded Chemistry
          Robert A. Goodnow Jr.
    3 A Brief History of DNA-Encoded Chemistry     45   (22)
          Anthony D. Keefe
    4 DNA-Compatible Chemistry                     67   (32)
          Kin-Chun Luk
          Alexander Lee Satz
    5 Foundations of a DNA-Encoded Library (Del)   99   (24)
          Alexander Lee Satz
    6 Exercises in the Synthesis of DNA-Encoded    123  (30)
    Libraries
          Steffen P. Creaser
          Raksha A. Acharya
    7 The DNA Tag: A Chemical Gene Designed for    153  (18)
    DNA-Encoded Libraries
          Andrew W. Fraley
    8 Analytical Challenges for DNA-Encoded        171  (30)
    Library Systems
          George L. Perkins
          G. John Langley
    9 Informatics: Functionality and               201  (12)
    Architecture for DNA-Encoded Library
    Production and Screening
          John A. Feinberg
          Zhengwei Peng
    10 Theoretical Considerations of the           213  (18)
    Application of DNA-Encoded Libraries to
    Drug Discovery
          Charles Wartchow
    11 Begin with the End in Mind: The             231  (16)
    Hit-to-Lead Process
          John Proudfoot
    12 Enumeration and Visualization of Large      247  (34)
    Combinatorial Chemical Libraries
          Sung-Sau So
    13 Screening Large Compound Collections        281  (38)
          Stephen P. Hale
    14 Reported Applications of DNA-Encoded        319  (30)
    Library Chemistry
          Johannes Ottl
    15 Dual-Pharmacophore DNA-Encoded Chemical     349  (8)
    Libraries
          Jorg Scheuermann
          Dario Neri
    16 HIT Identification and HIT Follow-Up        357  (20)
          Yixin Zhang
    17 Using DNA to Program Chemical Synthesis,    377  (40)
    Discover New Reactions, and Detect Ligand
    Binding
          Lynn M. McGregor
          David R. Liu
    18 The Changing Feasibility and Economics      417  (10)
    of Chemical Diversity Exploration with
    DNA-Encoded Combinatorial Approaches
          Robert A. Goodnow Jr.
    19 Keeping the Promise? An Outlook on DNA      427  (8)
    Chemical Library Technology
          Samu Melkko
          Johannes Ottl
Index                                              435