Amino Acids, Peptides and Proteins

[BOOK DESCRIPTION]

Amino Acids, Peptides and Proteins comprises a comprehensive review of significant developments at this biology/chemistry interface. Each volume of this Specialist Periodical Report opens with an overview of amino acids and their applications. Volume 37 marks the return of the series after a five-year hiatus, with Professors Etelka Farkas (Debrecen, Hungary) and Max Ryadnov (National Physical Laboratory, UK) as the new volume editors. There has been considerable progress in the field since the last publication in 2007, and predominantly this volume looks back over the last two year rather than the usual 12-months. However, traditional concepts are also revisited in the context of recent discoveries. Each chapter incorporates current trends of the reviewed topic and the authors' outlook of future perspectives. This is to facilitate the monitoring of the covered areas and their potentianl expansion with the inclusion of other specialist reports in subsequent volume. All chapters are compiled by leading researchers in their subject areas which offers this series as an appealing source of information for the research community in both academia and industry.

[TABLE OF CONTENTS]

Preface                                            v
          Etelka Farkas
          Maxim Ryadnov
    Amino acid and peptide bioconjugates           1  (39)
          Nikolett Mihala
          Ferenc Hudecz
        Introduction                               1  (1)
        Current trends                             1  (1)
      1 Amide bond forming reactions               2  (2)
      2 Reactions yielding a non-amide bond        4  (18)
      3 PEGylation                                 22 (1)
      4 Crosslinking agents                        22 (2)
      5 Selected applications of                   24 (16)
      peptide-bioconjugates
        References                                 31 (9)
    Self-assembling peptide materials              40 (26)
          Shuguang Zhang
      1 Introduction                               40 (7)
      2 General self-assembling peptide            47 (4)
      materials
      3 Diverse uses of self-assembling peptide    51 (4)
      nanofibers
      4 Surface modification self-assembling       55 (1)
      peptides
      5 Lipid-like self-assembling peptide         55 (6)
      surfactant materials
      6 Summary                                    61 (5)
        References                                 62 (4)
    Metal complexes of amino acids and peptides    66 (53)
          Etelka Farkas
          Imre Sovago
      1 Introduction                               66 (2)
      2 Amino acid complexes                       68 (17)
      3 Peptide Complexes                          85 (34)
        References                                 105(14)
    Model systems for folding and tertiary         119(32)
    contacts in peptides: A perspective from
    the physical sciences
          Jason Crain
      1 Introduction                               119(1)
      2 Thermodynamic basics of liquid mixtures    120(4)
      and hydrophobicity
      3 Current trends-in what state is the art?   124(7)
      4 Model systems for self-organization        131(13)
      5 Future perspectives                        144(7)
        References                                 146(5)
    Protein nanotubes, channels and cages          151(39)
          Jonathan G. Heddle
          Jeremy R. H. Tame
      1 Introduction                               151(3)
      2 Current trends                             154(1)
      3 Nanofibres (Amyloid-like fibrils)          155(2)
      4 Nanotubes                                  157(11)
      5 Cage proteins                              168(10)
      6 Channel proteins                           178(1)
      7 Examples of useful principles and          179(3)
      methods
      8 Ab initio design                           182(1)
      9 Future perspective and applications        182(8)
        References                                 183(7)
    Prescriptive peptide design                    190(48)
          Maxim G. Ryadnov
      1 Introduction                               190(1)
      2 Generic considerations for prescriptive    190(4)
      peptide design
      3 Structural space of de novo design         194(5)
      4 Current trends: structural rationales      199(12)
      5 Current trends: de novo motifs             211(18)
      6 Future perspectives                        229(9)
        References                                 230(8)
    Targeting alpha-helix based protein            238
    interactions; nuclear receptors as a case
    study
          Lech-Gustav Milroy
          Lidia Nieto
          Luc Brunsveld
      1 Introduction                               238(5)
      2 Nuclear receptors                          243(11)
      3 a-Helix-inspired drug discovery            254
        Conclusions                                265(1)
        References                                 266