Ultra-High Performance Liquid Chromatography and Its Applications

[BOOK DESCRIPTION]
This is the first resource to fully cover the instrumentation, method development, and applications of Ultra-High Performance Liquid Chromatography (U-HPLC). It details both the benefits and limitations of this method in the pharmaceutical industry, clinical research, the food industry, and environmental services. It covers U-HPLC topics coupled with ultra-violet detector (UV) and mass spectrometer (MS), instrumentation frequently used in solving complex molecules. This is an essential reference for scientists who utilize chromatographic techniques, including in academia, as well as pharmaceutical, biotechnology, chemical, food, environmental, and related industries.

[TABLE OF CONTENTS]

Preface                                            vii
Contributors                                       ix
    1 UHPLC Method Development                     1  (30)
          Shujun Chen
          Alireza Kord
    2 Method Transfer Between HPLC and UHPLC       31 (24)
    Platforms
          Gregory K. Webster
          Thomas F. Cullen
          Laila Kott
    3 Practical Aspects of Ultrahigh               55 (40)
    Performance Liquid Chromatography
          Naijun Wu
          Christopher J. Welch
          Theresa K. Natishan
          Hong Gao
          Tilak Chandrasekaran
          Li Zhang
    4 Coupling UHPLC with MS: The Needs,           95 (38)
    Challenges, and Applications
          Julie Schappler
          Serge Rudaz
          Jean-Luc Veuthey
          Davy Guillarme
    5 The Potential of Shell Particles in Fast     133(36)
    Liquid Chromatography
          Szabolcs Fekete
          Jeno Fekete
    6 UHPLC Determination of Drugs of Abuse in     169(28)
    Human Biological Matrices
          Fabio Gosetti
          Eleonora Mazzucco
          Maria Carla Gennaro
    7 UHPLC in the Analyses of Isoflavones and     197(38)
    Flavonoids
          Sylwia Magiera
          Irena Baranowska
    8 UHPLC for Characterization of Protein        235(18)
    Therapeutics
          Jennifer C. Rea
          Yajun Jennifer Wang
          Taylor Zhang
    9 UHPLC/MS Analysis of Illicit Drugs           253(18)
          Guifeng Jiang
          Jason R. Stenzel
          Ray Chen
          Diab Elmashni
    10 Ultra-High Performance Liquid               271(20)
    Chromatography - Mass Spectrometry and Its
    Application
          Zhili Xiong
          Ying Deng
          Famei Li
Index                                              291