Bio-interactions of Nano Materials
[Book Description]
An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues. Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials.These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.
[Table of Contents]
Foreword ix
Preface xi
Editors xiii
Contributors xv
Chapter 1 Introduction---Biointeractions of 1 (48)
Nanomaterials: Challenges and Solutions
Vijaykumar B. Sutariya
Vrinda Pathak
Ana Groshev
Mahavir B. Chougule
Sachin Naik
Deepa Patel
Yashwant Pathak
Chapter 2 Nanoparticle Exposures in 49 (24)
Occupational Environments
Li-Hao Young
Ying-Fang Wang
Ching-Hwa Chen
Chun-Wan Chen
Perng-Jy Tsai
Chapter 3 Physicochemical 73 (30)
Characterization-Dependent Toxicity of
Nanoparticles
Jigar N. Shah
Ankur P. Shah
Hiral J. Shah
Vijaykumar B. Sutariya
Chapter 4 Cytotoxicity of 103 (14)
Stimuli-Responsive Nanomaterials:
Predicting Clinical Viability through
Robust Biocompatibility Profiles
Daniel Wehrung
Moses O. Oyewumi
Chapter 5 Biosensing Devices for Toxicity 117 (14)
Assessment of Nanomaterials
Evangelia Hondroulis
Pratik Shah
Xuena Zhu
Chen-Thong Li
Chapter 6 Carbon Nanotubes and Pulmonary 131 (10)
Toxicity
Malay K. Das
Charles Preuss
Chapter 7 Nanotoxicity of Polymeric and 141 (18)
Solid Lipid Nanoparticles
Dev Prasad
Harsh Chauhan
Chapter 8 Analytical Characterization of 159 (16)
Nanomaterials in Biological Matrices for
Hazard Assessment
Mingsheng Xu
Daisuke Fujita
Huanxing Su
Hongzheng Chen
Nobutaka Hanagata
Chapter 9 Nanoparticles and Human Health: A 175 (34)
Review of Epidemiological Studies
Vijaykumar B. Sutariya
Ana Groshev
Vivek Dave
Hardeep Saluja
Deepak Bhatia
Prabodh Sadana
Yashwant Pathak
Chapter 10 Toxicogenomic Approaches to 209 (16)
Understanding the Toxicity of Nanoparticles
Qiwen Shi
Mahavir B. Chougule
Vijaykumar B. Sutariya
Deepak Bhatia
Chapter 11 Nanomaterial-Based Gene and Drug 225 (24)
Delivery: Pulmonary Toxicity Considerations
Mahavir B. Chougule
Rakesh K. Tekade
Peter R. Hoffmann
Deepak Bhatia
Vijaykumar B. Sutariya
Yashwant Pathak
Chapter 12 Cardiovascular Toxicity of 249 (10)
Nanomaterials
Saijie Zhu
Minghuang Hong
Chapter 13 Toxicity of Nanomaterials on the 259 (26)
Gastrointestinal Tract
Jayvadan Patel
Vibha Champavat
Chapter 14 Toxicity of Nanomaterials on the 285 (30)
Liver, Kidney, and Spleen
Jayvadan Patel
Anita Patel
Chapter 15 Regulatory Implications of 315 (32)
Nanotechnology
Lynn L. Bergeson
Michael F. Cole
Chapter 16 Ocular Toxicity of Nanoparticles 347 (6)
Aditya Grover
Anjali Hirani
Yong Woo Lee
Vijaykumar B. Sutariya
Yashwant Pathak
Chapter 17 Genotoxicity of Nanoparticles 353 (12)
Amaya Azqueta
Leire Arbillaga
Adela Lopez de Cerain
Chapter 18 Interactions of 365 (18)
Polysaccharide-Coated Nanoparticles with
Proteins
Christine Vauthier
Chapter 19 Models for Risk Assessments of 383 (42)
Nanoparticles
Sanjay Dey
Bhaskar Mazumder
Yaswant Pathak
Chapter 20 Immunotoxicity of Carbon 425 (18)
Nanoparticles
Paulami Pal
Bhaskar Mazumder
Yaswant Pathak
Index 443